Hydrochloric Acid → HCID 67542448, compound

Participants

Reaction Steps

Hydrogen chloride (20 mL of a 4 M solution in 1,4-dioxane) was added to a stirred suspension of tert-butyl(4-amino[1,3]thiazolo[4,5-c]quinolin-2-yl)methoxycarbamate (3.63 g, 10.5 mmol) in dichloromethane (80 mL). The reaction was stirred for 4.5 hours at room temperature and then concentrated under reduced pressure to provide 3.65 g of 2-(aminooxy)methyl[1,3]thiazolo[4,5-c]quinolin-4-amine trihydrochloride as a yellow solid.

Provenance & Evidence