Hydrochloric Acid → HCID 67542448, compound

HRID 389070Notes

Reaction equation

HRID 389070 reaction equation
[ClH:1].C(OC(=O)[NH:8][O:9][CH2:10][C:11]1[S:12][C:13]2[C:22]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[N:16]=[C:15]([NH2:23])[C:14]=2[N:24]=1)(C)(C)C>O1CCOCC1.ClCCl>[ClH:1].[ClH:1].[ClH:1].[NH2:8][O:9][CH2:10][C:11]1[S:12][C:13]2[C:22]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[N:16]=[C:15]([NH2:23])[C:14]=2[N:24]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 131730232HCID 131730232, compound

Product 1

HCID 67542448HCID 67542448, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

Hydrogen chloride (20 mL of a 4 M solution in 1,4-dioxane) was added to a stirred suspension of tert-butyl(4-amino[1,3]thiazolo[4,5-c]quinolin-2-yl)methoxycarbamate (3.63 g, 10.5 mmol) in dichloromethane (80 mL). The reaction was stirred for 4.5 hours at room temperature and then concentrated under reduced pressure to provide 3.65 g of 2-(aminooxy)methyl[1,3]thiazolo[4,5-c]quinolin-4-amine trihydrochloride as a yellow solid.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-7ece8d776cc44e30bcb4b8f3c7e5d875
Source dataset
uspto-grants-2013_02
Patent number
US08378102B2

Reaction notes

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