Hydrochloric Acid → HCID 44469454, compound

HRID 38908Notes

Reaction equation

HRID 38908 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[O:18][C:17]3[CH:19]=[C:20]([S:23]([CH3:26])(=[O:25])=[O:24])[CH:21]=[CH:22][C:16]=3[O:15][CH2:14]2)(=O)=O)=CC=1.[CH2:27]([NH:30][CH2:31][CH2:32][CH3:33])[CH2:28][CH3:29].Cl>C(#N)C>[CH3:26][S:23]([C:20]1[CH:21]=[CH:22][C:16]2[O:15][CH2:14][CH:13]([CH2:12][N:30]([CH2:31][CH2:32][CH3:33])[CH2:27][CH2:28][CH3:29])[O:18][C:17]=2[CH:19]=1)(=[O:24])=[O:25]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8902DipropylamineHCID 86652933[7-(Methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate

Product 1

HCID 44469454HCID 44469454, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation according to Example 14 using [7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate (0.175 g, 0.44 mmol), N-propylpropan-1-amine (1 ml) and ACN (3 ml). Yield: 0.11 g, 77%. The amine was converted to the hydrochloric acid salt and crystallized from MeOH/Et2O. M.p. 182° C. MS m/z (rel. intensity, 70 eV) 327 (M+, 1) 114 (100), 298 (17), 115 (8), 86 (6).

Workup

  1. customPreparation
  2. customcrystallized from MeOH/Et2O

Sources & evidence

ORD record
ord-8445e0a7fa5b41efb13ca07e7e27267b
Source dataset
uspto-grants-2013_09
Patent number
US08524766B2

Reaction notes

Loading…