Hydrogen chloride-ethyl acetate → HCID 67024400, compound

HRID 389097Notes

Reaction equation

HRID 389097 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([O:12][C:13]([CH3:26])([CH3:25])[C:14]([NH:16][NH:17]C(OC(C)(C)C)=O)=[O:15])=[CH:4][CH:3]=1.C(OCC)(=O)C.Cl>C(OCC)(=O)C>[ClH:1].[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([O:12][C:13]([CH3:26])([CH3:25])[C:14]([NH:16][NH2:17])=[O:15])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 67024448HCID 67024448, compound

Product 1

HCID 67024400HCID 67024400, compoundYield 166.4%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Tert-butyl 2-{2-[(4-chloro-1-naphthyl)oxy]-2-methylpropanoyl}hydrazinecarboxylate (6.11 g) was dissolved in ethyl acetate (40 ml), 4M hydrogen chloride-ethyl acetate (20 ml) was added thereto, followed by stirring at room temperature for 8 hours. The solvent was evaporated under reduced pressure and the residue was washed with diisopropylether to obtain, as a white solid, 2-[(4-chloro-1-naphthyl)oxy]-2-methylpropanohydrazide monohydrochloride (4.23 g).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. washthe residue was washed with diisopropylether

Sources & evidence

ORD record
ord-e5a2b421d89a4886b588f165dbf395c1
Source dataset
uspto-grants-2013_02
Patent number
US08377923B2

Reaction notes

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