反应详情

Methyl 3-cyclopropyl-3-oxopropanoate (2.0 g) and magnesium perchlorate (940 mg) were dissolved in ethyl acetate (20 ml), followed by stirring at room temperature for 5 minutes, and N-bromosuccinimide (2.76 g) was added thereto, followed by stirring at room temperature for 4 hours. Water was added thereto, followed by extraction with ethyl acetate, the organic layer was washed with water and saturated brine and was dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to obtain, as a colorless oily product, methyl 2-bromo-3-cyclopropyl-3-oxopropanoate (3.32 g).

1. stirringby stirring at room temperature for 4 hours
2. extractionfollowed by extraction with ethyl acetate
3. washthe organic layer was washed with water and saturated brine
4. dry with materialwas dried over anhydrous magnesium sulfate
5. customthe solvent was evaporated under reduced pressure