反应详情

温度

100 °C

Ethyl 2-(4-bromo-2,6-difluorophenoxy)-2-methylpropanoate (200 mg), tetrakis-triphenylphosphine palladium (36 mg) and sodium carbonate (200 mg) were dissolved in a mixed solvent of dioxane (4.0 ml) and water (1.0 ml), trimethylboroxine (0.26 ml) was added thereto, followed by stirring under an argon atmosphere at 100° C. overnight. After cooling to room temperature, an insoluble substance was removed by celite filtration and the solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography to obtain, as a colorless oily product, ethyl 2-(2,6-difluoro-4-methylphenoxy)-2-methylpropanoate (115 mg).

1. additionwas added
2. temperatureAfter cooling to room temperature
3. customan insoluble substance was removed by celite filtration
4. customthe solvent was evaporated under reduced pressure
5. customThe residue was purified by silica gel chromatography