HCID 62683031, compound → HCID 63360593, compound

HRID 389113Notes

Reaction equation

HRID 389113 reaction equation
[CH2:1]([NH:3][C:4](=[O:16])[C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[C:7]([NH:14][CH3:15])[CH:6]=1)[CH3:2]>C(O)C.[C].[Pd]>[NH2:11][C:8]1[CH:9]=[CH:10][C:5]([C:4]([NH:3][CH2:1][CH3:2])=[O:16])=[CH:6][C:7]=1[NH:14][CH3:15]

Participants

4

Reactant 1

HCID 62683031HCID 62683031, compound

Product 1

HCID 63360593HCID 63360593, compoundYield 112%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

10% palladium-carbon (containing 50% water, 500 mg) was added to a solution of N-ethyl-3-(methylamino)-4-nitrobenzamide (1.99 g) in ethanol (50 ml), followed by stirring at ambient pressure under a hydrogen atmosphere for 15 hours. The reaction solution was filtered with celite and the solvent was evaporated under reduced pressure to obtain 4-amino-N-ethyl-3-(methylamino)benzamide (1.93 g) as a light red-purple oily product.

Workup

  1. filtrationThe reaction solution was filtered with celite
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-5e8abad73d9e43d98d4c837ce28bc11a
Source dataset
uspto-grants-2013_02
Patent number
US08377923B2

Reaction notes

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