Hydrochloric Acid → Ethyl (25)-2-aminonon-8-enoate hydrochloride

HRID 389176Notes

Reaction equation

HRID 389176 reaction equation
C(OC([NH:8][C@@H:9]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH:18]=[CH2:19])[C:10]([OH:12])=[O:11])=O)(C)(C)C.[ClH:20].[CH3:21][CH2:22]O>>[ClH:20].[NH2:8][C@@H:9]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH:18]=[CH2:19])[C:10]([O:12][CH2:21][CH3:22])=[O:11]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 11507316(2S)-N-Boc-amino-non-8-enoic acid

Product 1

HCID 131730233Ethyl (25)-2-aminonon-8-enoate hydrochloride

Procedure

A stirred solution of (2S)-2-[(t-butoxycarbonyl)amino]non-8-enoic acid (ACME Bioscience Inc) (1.00 g, 3.69 mmol) in EtOH (10 ml) was saturated with HCl gas. The mixture was stirred at RT for 2 hours, then concentrated to give the title product (0.85 g). LRMS (ESI) m/z 200.4 [(M+H)+; calcd for C11H22NO2: 200.2].

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-dacf9470c6444e89b238b991ee32dd5e
Source dataset
uspto-grants-2013_02
Patent number
US08377874B2

Reaction notes

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