HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Methyl (4R)-4-[(7-methoxy-3-vinylquinolin-2-yl)oxy]-L-prolinate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-t-Butyl 2-methyl (2S,4R)-4-[(7-methoxy-3-vinylquinolin-2-yl)oxy]pyrrolidine-1,2-dicarboxylate | HCID 59287274 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Methyl (4R)-4-[(7-methoxy-3-vinylquinolin-2-yl)oxy]-L-prolinate hydrochloride | HCID 66895950 | — |
Reaction Steps
A solution of 1-t-butyl 2-methyl (2S,4R)-4-[(7-methoxy-3-vinylquinolin-2-yl)oxy]pyrrolidine-1,2-dicarboxylate (0.85 g, 1.98 mmol) in 4M HCl in dioxane (10 mL) was stirred at RT for two hours. The reaction mixture was concentrated, and the product was used with no further purification. LRMS (M+H-tBu)+=329.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08377874B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-d16c663562324c14959f82a69853d708 |
| Source note | uspto-grants-2013_02 |