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HRID38923

反应详情

EQUATION

反应方程式

HRID 38923 的结构方程式

REACTANTS

反应物

3
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CCN
HCID6341

Ethanamine

C2H7N

结构：Cc1ccc(S(=O)(=O)OC[C@H]2COc3c(Cl)cc(S(C)(=O)=O)cc3O2)cc1
HCID86652939

未命名化合物

PRODUCTS

生成物

1
结构：CCNC[C@H]1COc2c(Cl)cc(S(C)(=O)=O)cc2O1
HCID44470011

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

Preparation according to Example 5 using [(2R)-5-chloro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate (0.47 g, 1.09 mmol), ethanamine (1 ml, 70% in water) and ACN (7 ml). Yield: 0.278 g, 83%. The amine was converted to the hydrochloric acid salt and crystallized from MeOH/Et2O. M.p. 267° C. MS m/z (rel. intensity, 70 eV) 305 (M+, 4), 63 (3), 59 (4), 58 (bp), 56 (5). [α]=−62° (MeOH).

WORKUP

后处理

  1. customPreparation
  2. customcrystallized from MeOH/Et2O
  3. custom[α]=−62° (MeOH)