HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 389239Generated: October 27, 2026
3-Methyl-2-butanone → 5-Methoxy-2,3,3-trimethyl-3H-indole
https://huagongshe.com/reaction/389239
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Methyl-2-butanone | HCID 11251 | — |
| Reactant | 4-Methoxyphenylhydrazine hydrochloride | HCID 2723904 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-Methoxy-2,3,3-trimethyl-3H-indole | HCID 11095392 | — |
Reaction Steps
To 4-methoxyphenyl hydrazine hydrochloride (4.84 g) was added 3-methyl-2-butanone (6.4 ml) and acetic acid (45 ml). The mixture was heated to 10° C. for 2.5 hours after which time the solvent was removed by rotary evaporation. Flash column chromatography gave the product (4.66 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08378120B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-0f58494c1ef14cdc90d2e0dcd78b2684 |
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| Source note | uspto-grants-2013_02 |
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