反应详情

2-Chloro-5-methyl-pyridine-3-carbaldehyde (0.22 g, 1.41 mmol), ethylamine (2M in THF; 1.06 mL, 2.12 mmol), and sodium cyanoborohydride (0.133 g, 2.12 mmol) were combined in MeOH (2.52 mL). Acetic acid (0.12 mL, 2.12 mmol) was added, and the reaction was stirred at room temperature for 1 hour. The mixture was concentrated, and the residue was dissolved in CH2Cl2, washed with saturated aqueous NaHCO3, concentrated, and purified by silica gel chromatography (0-10% MeOH in CH2Cl2) to give the title compound.

1. concentrationThe mixture was concentrated
2. dissolutionthe residue was dissolved in CH2Cl2
3. washwashed with saturated aqueous NaHCO3
4. concentrationconcentrated
5. custompurified by silica gel chromatography (0-10% MeOH in CH2Cl2)