Cyclopropanecarbonyl chloride → HCID 58579960, compound

HRID 389289Notes

Reaction equation

Cl.Cl.[CH2:3]([O:5][C:6](=[O:35])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([C:16]2[C:17]([CH2:26][NH:27][CH2:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[N:18][C:19]3[C:24]([CH:25]=2)=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:9]=1)[CH3:4].[CH:36]1([C:39](Cl)=[O:40])[CH2:38][CH2:37]1>>[CH2:3]([O:5][C:6](=[O:35])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([C:16]2[C:17]([CH2:26][N:27]([CH2:28][C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)[C:39]([CH:36]3[CH2:38][CH2:37]3)=[O:40])=[N:18][C:19]3[C:24]([CH:25]=2)=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:9]=1)[CH3:4]

Participants

Reactant 2

HCID 77637Cyclopropanecarbonyl chloride

HCID 131730236HCID 131730236, compound

Product 1

HCID 58579960HCID 58579960, compound

Procedure

Prepared according to the procedure described in Example 5, Step 5, using the following starting materials: {3-[2-(benzylamino-methyl)-quinolin-3-yl]-4-methoxy-phenyl}-acetic acid ethyl ester, dihydrochloride and cyclopropanecarbonyl chloride.

Workup

customPrepared

Sources & evidence

ORD record: ord-dbe799c324f140679bf6b5d6d49ca2bd
Source dataset: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08378107B2

Reaction notes

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