HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 7-methoxy-2,3-dihydro-1H-inden-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | 2,3-Dihydro-4,7-dimethoxy-1H-indene | HCID 12654133 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 7-methoxy-2,3-dihydro-1H-inden-4-ol | HCID 20609156 | — |
Reaction Conditions
| Temperature | 5 °C |
|---|
Reaction Steps
To the clear solution of 4,7-Dimethoxyindane (22.5 gm, 0.126 mole) in Methylene chloride (400 ml), added Boron tribromide (12.27 ml, 0.13 mole) at 0° C. After 2 hours stirring at 0-10° C., water (100 ml) was added and then the reaction mixture was extracted with Methylene chloride. The Methylene chloride layer was dried over Sodium sulphate and distilled off to give a crude mass which was purified by column chromatography using 7% Ethyl acetate in Hexane (9.0 gm).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08378118B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-6dc2ab116f0b42ac90f202ae09650e77 |
| Source note | uspto-grants-2013_02 |