反应详情

温度

70 °C

To a stirred solution of 3-(7-Methoxy-6-methyl-indan-4-ylmethyl)-pentane-2,4-dione (1.0 gm 0.0036 mole) in Ethanol (15 ml), a solution of 2-Hydrazino-ethanol (0.33 gm, 0.0043 mole) in Ethanol (5 ml) was added at 25-30° C. and reaction mixture was heated to 70° C. for an hour. The Acetic acid (2 ml) was added. Further the reaction mixture was stirred at 70° C. for 3 hours. Ethanol was distilled under vacuum to give a residue which was partitioned between Ethyl acetate (50 ml) and water (25 ml). Ethyl acetate was distilled under vacuum to give a crude product The crude product was solidified after stirring in Diethyl ether (10 ml). The solid was filtered under vacuum and dried to give a 700 mg of desired compound as a solid.

1. customreaction mixture
2. distillationEthanol was distilled under vacuum
3. customto give a residue which
4. customwas partitioned between Ethyl acetate (50 ml) and water (25 ml)
5. distillationEthyl acetate was distilled under vacuum
6. customto give a crude product The crude product
7. filtrationThe solid was filtered under vacuum
8. customdried