Diethylamine → N-Ethyl-N-{[5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-YL]methyl}ethanamine

HRID 38931Notes

Reaction equation

HRID 38931 reaction equation
[F:1][C:2]1[C:11]2[O:10][CH2:9][CH:8]([CH2:12]OS(C3C=CC(C)=CC=3)(=O)=O)[O:7][C:6]=2[CH:5]=[C:4]([S:24]([CH3:27])(=[O:26])=[O:25])[CH:3]=1.[CH2:28]([NH:30][CH2:31][CH3:32])[CH3:29]>C(#N)C>[CH2:28]([N:30]([CH2:12][CH:8]1[O:7][C:6]2[CH:5]=[C:4]([S:24]([CH3:27])(=[O:25])=[O:26])[CH:3]=[C:2]([F:1])[C:11]=2[O:10][CH2:9]1)[CH2:31][CH3:32])[CH3:29]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 86652936[5-Fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate

Product 1

HCID 44470018N-Ethyl-N-{[5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-YL]methyl}ethanamine

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation according to Example 42 using [5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl-4-methylbenzenesulfonate (0.005 g, 0.012 mmol), N-ethylethanamine (0.5 ml), ACN (2.5 ml). MS m/z (rel. intensity, 70 eV) 317 (M+, 0.2), 87 (6), 86 (bp), 58 (5), 56 (3).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-4b82f00999e24a18ba112c743bff9a75
Source dataset
uspto-grants-2013_09
Patent number
US08524766B2

Reaction notes

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