反应详情

温度

0 °C

The stirred solution of 7-methoxy-6-methyl-indan-4-carbaldehyde (1.0 gm, 0.0060 mole) in Methanol (20 ml), Sulphuric acid (0.6 ml) was added at room temperature. To the reaction mixture, 30% Hydrogen peroxide (1.6 ml) was added and stirred for 1 hour at 0° C. Methanol was distilled under vacuum and the residue was dissolved in Ethylacetate (50 ml), further ethyl acetate layer was washed with water and evaporated to give a crude product, which upon triturating with Hexane give 600 mg title compound as a solid.

1. distillationMethanol was distilled under vacuum
2. dissolutionthe residue was dissolved in Ethylacetate (50 ml)
3. washfurther ethyl acetate layer was washed with water
4. customevaporated
5. customto give a crude product, which
6. customupon triturating with Hexane