反应详情

To a solution of Example 3 product (i.e. N-benzyl-O-methyl-N2-trityl-D-serinamide, 50 g) in dichloromethane (100 ml), hydrochloric acid (36%) was added at room temperature. This solution was stirred for 30 minutes at room temperature and then the solvent was completely recovered under vacuum at 40° C. Water (250 ml) was added to it at room temperature and the aqueous layer was neutralized with aqueous ammonia (20 ml). The aqueous layer was extracted with toluene (2×200 ml). The toluene was then completely recovered under vacuum at 50° C. to 55° C. to get an oil. Yield=15 gm.

1. customthe solvent was completely recovered under vacuum at 40° C
2. additionWater (250 ml) was added to it at room temperature
3. extractionThe aqueous layer was extracted with toluene (2×200 ml)
4. customThe toluene was then completely recovered under vacuum at 50° C. to 55° C.
5. customto get an oil