Iodoethane → HCID 66759564, compound

HRID 389430Notes

Reaction equation

HRID 389430 reaction equation
[Cl:1][C:2]1[O:12][C:5]2=[C:6]([NH2:11])[N:7]=[CH:8][C:9]([I:10])=[C:4]2[CH:3]=1.I[CH2:14][CH3:15]>>[Cl:1][C:2]1[O:12][C:5]2=[C:6]([NH:11][CH2:14][CH3:15])[N:7]=[CH:8][C:9]([I:10])=[C:4]2[CH:3]=1

Participants

3

Reactant 2

HCID 6340IodoethaneHCID 667601342-Chloro-4-iodofuro[2,3-c]pyridin-7-amine

Product 1

HCID 66759564HCID 66759564, compoundYield 45%

Procedure

The title compound was prepared in 45% yield from 2-chloro-4-iodo-furo[2,3-c]pyridin-7-ylamine and iodoethane by a procedure analogous to Intermediate 7. 1H NMR (400 MHz, CDCl3): δ 8.08 (s, 1 H), 6.47 (s, 1 H), 4.71 (br. s., 1 H), 3.59 (qd, J=5.6, 7.2 Hz, 2 H), 1.31 (t, J=7.2 Hz, 3 H); MS (ESI): 322.96, 324.96 [M+H]+; HPLC tR=3.75 min (ZQ3: polar—4 min).

Workup

  1. customHPLC tR=3.75 min (ZQ3: polar—4 min)

Sources & evidence

ORD record
ord-c5fad4ab98de47cc966034e6f1051497
Source dataset
uspto-grants-2013_02
Patent number
US08378104B2

Reaction notes

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