4-Iodo-2-(isoquinolin-5-yl)furo[2,3-c]pyridin-7-amine → 2-(1-Benzothiophen-7-yl)-4-iodofuro[2,3-c]pyridin-7-amine

HRID 389433Notes

Reaction equation

HRID 389433 reaction equation
[S:1]1[C:5]2[C:6]([C:10]3[O:19][C:13]4=[C:14]([NH2:18])[N:15]=[CH:16][CH:17]=[C:12]4[CH:11]=3)=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[CH:2]1.[I:20]C1C=NC(N)=C2OC(C3C=CC=C4C=3C=CN=C4)=CC=12>>[S:1]1[C:5]2[C:6]([C:10]3[O:19][C:13]4=[C:14]([NH2:18])[N:15]=[CH:16][C:17]([I:20])=[C:12]4[CH:11]=3)=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[CH:2]1

Participants

3

Reactant 2

HCID 667594744-Iodo-2-(isoquinolin-5-yl)furo[2,3-c]pyridin-7-amineHCID 667602702-(1-Benzothiophen-7-yl)furo[2,3-c]pyridin-7-amine

Product 1

HCID 667599752-(1-Benzothiophen-7-yl)-4-iodofuro[2,3-c]pyridin-7-amineYield 51%

Procedure

The title compound was prepared in 51% yield from 2-(1-benzothiophen-7-yl)furo[2,3-c]pyridin-7-amine by a procedure analogous to Intermediate 10, Step B. 1H NMR (300 MHz, DMSO-d6) δ 8.20 (d, J=7.5 Hz, 1H), 8.01 (d, J=7.6 Hz, 1H), 7.95 (d, J=1.5 Hz, 2H), 7.64-7.58 (m, 2H). 7.18 (s, 1H). 6.67 (br s, 2H).

Sources & evidence

ORD record
ord-c126ca1747fb473e86aa382492d6784f
Source dataset
uspto-grants-2013_02
Patent number
US08378104B2

Reaction notes

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