反应详情

A mixture of 1,2,3-benzothiadiazol-4-amine (200.0 mg, 1.323 mmol) and NBS (341.4 mg, 1.918 mmol) in THF (10 mL) was stirred at RT overnight. The solution was adsorbed onto silica gel and purified by ISCO chromatography (10 to 30% EtOAc:heptane) to afford 80 mg (30%) of the title compound as a yellow solid. 1H NMR (400 MHz, DMSO-d6): δ 6.74 (d, J=8.3 Hz, 1 H), 6.97 (s, 2 H), 7.60 (d, J=8.3 Hz, 1 H).

1. custompurified by ISCO chromatography (10 to 30% EtOAc:heptane)