tert-Butyl 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]azetidine-1-carboxylate → HCID 66760943, compound

Participants

Reaction Steps

The title compound was prepared from 4-iodo-2-thieno[2,3-c]pyridine-3-yl-furo[2,3-c]pyridine-7-ylamine and tert-butyl 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]azetidine-1-carboxylate by a procedure analogous to Example 68 followed by deprotection by a procedure analogous to Example 64, Step B. 1H NMR (400 MHz, CD3OD): δ 9.29 (s, 1 H), 8.75 (s, 1 H), 8.63 (d, J=6.1 Hz, 1 H), 8.59 (d, J=6.1 Hz, 1 H), 8.26 (s, 1 H), 8.08 (s, 1H), 7.96 (s, 1H), 7.62 (s, 1H), 5.32 (m, 1H), 4.45 (m, 4H); MS (ESI): 389.18 [M+H]+; HPLC tR=0.25 min (HPLC: Analytical—2 min).

Provenance & Evidence