Methylamine → N-Methyl-1-[7-(methylsulfonyl)-3,4-dihydro-2H-chromen-2-YL]methanamine

HRID 38962Notes

Reaction equation

HRID 38962 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:22][CH2:21][C:20]3[C:15](=[CH:16][C:17]([S:23]([CH3:26])(=[O:25])=[O:24])=[CH:18][CH:19]=3)[O:14]2)(=O)=O)=CC=1.[CH3:27][NH2:28]>C(#N)C>[CH3:27][NH:28][CH2:12][CH:13]1[CH2:22][CH2:21][C:20]2[C:15](=[CH:16][C:17]([S:23]([CH3:26])(=[O:25])=[O:24])=[CH:18][CH:19]=2)[O:14]1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 86652940[7-(methylsulfonyl)-3,4-dihydro-2H-chromen-2-yl]methyl 4-methylbenzenesulfonate

Product 1

HCID 44470302N-Methyl-1-[7-(methylsulfonyl)-3,4-dihydro-2H-chromen-2-YL]methanamine

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation according to Example 25: [7-(methylsulfonyl)-3,4-dihydro-2H-chromen-2-yl]methyl 4-methylbenzenesulfonate (0.020 g, 0.0504 mmol), methanamine (33% in EtOH, 0.5 ml), ACN (3 ml). MS m/z (rel. intensity, 70 eV) 255 (M+, 92), 132 (52), 131 (bp), 77 (76), 70 (48).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-86b9338a40e549aab014e9d31ea867f9
Source dataset
uspto-grants-2013_09
Patent number
US08524766B2

Reaction notes

Loading…