Trifluoroacetic acid → HCID 67155149, compound

HRID 389646Notes

Reaction equation

HRID 389646 reaction equation
[CH3:1][O:2][C:3](=[O:23])[C@@H:4]([NH:15]C(OC(C)(C)C)=O)[CH2:5][NH:6][C:7]([C:9]1[S:10][C:11]([Cl:14])=[CH:12][CH:13]=1)=[O:8].[C:24]([OH:30])([C:26]([F:29])([F:28])[F:27])=[O:25]>C(Cl)Cl>[F:27][C:26]([F:29])([F:28])[C:24]([OH:30])=[O:25].[CH3:1][O:2][C:3](=[O:23])[C@@H:4]([NH2:15])[CH2:5][NH:6][C:7]([C:9]1[S:10][C:11]([Cl:14])=[CH:12][CH:13]=1)=[O:8]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67155290(S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(5-chlorothiophene-2-carboxamido)propanoate

Product 1

HCID 67155149HCID 67155149, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Intermediate 8 (13.3 g, 36.66 mmol) in 75 ml DCM was treated with 25 ml TFA and stirred overnight at RT. The solvents were evaporated and the residue was dissolved in DCM and evaporated again. Yield: 21 g (TFA-salt), oil, crude material

Workup

  1. customThe solvents were evaporated
  2. dissolutionthe residue was dissolved in DCM
  3. customevaporated again

Sources & evidence

ORD record
ord-e2c79178452648019567c3ab04c5d292
Source dataset
uspto-grants-2013_02
Patent number
US08378092B2

Reaction notes

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