HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Piperidone → 1-(3-Benzylsulfanyl-2-trifluoromethyl-phenyl)piperidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Piperidone | HCID 12665 | — |
| Reactant | 1-Benzylsulfanyl-3-bromo-2-trifluoromethyl-benzene | HCID 67155259 | — |
| Product | 1-(3-Benzylsulfanyl-2-trifluoromethyl-phenyl)piperidin-2-one | HCID 67155501 | — |
Reaction Steps
Intermediate 24 (10.5 g, 30.24 mmol) was coupled with piperidin-2-one (3.597 g, 36.29 mmol) in close analogy to the procedure described in step 1.6). After workup the crude oil is purified by chromatography on silica gel (n-heptane-ethyl acetate 4:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08378092B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-daad2dec2bdb4c1e8ff7dba84cf6f138 |
| Source note | uspto-grants-2013_02 |