Butylamine → N-{[7-(Methylsulfonyl)-3,4-dihydro-2H-chromen-2-YL]methyl}butan-1-amine

HRID 38966Notes

Reaction equation

HRID 38966 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:22][CH2:21][C:20]3[C:15](=[CH:16][C:17]([S:23]([CH3:26])(=[O:25])=[O:24])=[CH:18][CH:19]=3)[O:14]2)(=O)=O)=CC=1.[CH2:27]([NH2:31])[CH2:28][CH2:29][CH3:30]>C(#N)C>[CH3:26][S:23]([C:17]1[CH:16]=[C:15]2[C:20]([CH2:21][CH2:22][CH:13]([CH2:12][NH:31][CH2:27][CH2:28][CH2:29][CH3:30])[O:14]2)=[CH:19][CH:18]=1)(=[O:24])=[O:25]

Participants

4

Reactant 2

HCID 8007ButylamineHCID 86652940[7-(methylsulfonyl)-3,4-dihydro-2H-chromen-2-yl]methyl 4-methylbenzenesulfonate

Product 1

HCID 44468515N-{[7-(Methylsulfonyl)-3,4-dihydro-2H-chromen-2-YL]methyl}butan-1-amine

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation according to Example 25: [7-(methylsulfonyl)-3,4-dihydro-2H-chromen-2-yl]methyl 4-methylbenzenesulfonate (0.020 g, 0.0504 mmol), butan-1-amine (0.5 ml), ACN (3 ml). MS m/z (rel. intensity, 70 eV) 297 (M+, 6), 254 (9), 131 (8), 87 (7), 86 (bp), 77 (7).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-6e4595910f8c4bae916cc332812ac131
Source dataset
uspto-grants-2013_09
Patent number
US08524766B2

Reaction notes

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