Piperazine → HCID 67155375, compound

HRID 389662Notes

Reaction equation

HRID 389662 reaction equation
[Cl:1][C:2]1[C:7]([N:8]2[CH2:12][CH2:11][CH2:10][C:9]2=[O:13])=[CH:6][CH:5]=[CH:4][C:3]=1[S:14]([NH:17][C@@H:18]([CH2:22][NH:23][C:24]([C:26]1[S:27][C:28]([Cl:31])=[CH:29][CH:30]=1)=[O:25])[C:19]([OH:21])=O)(=[O:16])=[O:15].[NH:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1>>[Cl:1][C:2]1[C:7]([N:8]2[CH2:12][CH2:11][CH2:10][C:9]2=[O:13])=[CH:6][CH:5]=[CH:4][C:3]=1[S:14]([NH:17][C@H:18]([C:19](=[O:21])[N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1)[CH2:22][NH:23][C:24]([C:26]1[S:27][C:28]([Cl:31])=[CH:29][CH:30]=1)=[O:25])(=[O:16])=[O:15]

Participants

3

Reactant 2

HCID 4837PiperazineHCID 67155325HCID 67155325, compound

Product 1

HCID 67155375HCID 67155375, compound

Procedure

Intermediate 47 (150 mg, 0.3 mmol) and piperazine (25.5 mg, 0.3 mmol) were coupled in close analogy to the procedure described in 3.5). The mixture was purified by prep.

Workup

  1. customThe mixture was purified by prep

Sources & evidence

ORD record
ord-3f4f1fe580824bd2a48a5b485f40b81b
Source dataset
uspto-grants-2013_02
Patent number
US08378092B2

Reaction notes

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