Diethylamine → N-Ethyl-N-{[7-(methylsulfonyl)-3,4-dihydro-2H-chromen-2-YL]methyl}ethanamine

HRID 38969Notes

Reaction equation

HRID 38969 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:22][CH2:21][C:20]3[C:15](=[CH:16][C:17]([S:23]([CH3:26])(=[O:25])=[O:24])=[CH:18][CH:19]=3)[O:14]2)(=O)=O)=CC=1.[CH2:27]([NH:29][CH2:30][CH3:31])[CH3:28]>C(#N)C>[CH2:27]([N:29]([CH2:12][CH:13]1[CH2:22][CH2:21][C:20]2[C:15](=[CH:16][C:17]([S:23]([CH3:26])(=[O:24])=[O:25])=[CH:18][CH:19]=2)[O:14]1)[CH2:30][CH3:31])[CH3:28]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 86652940[7-(methylsulfonyl)-3,4-dihydro-2H-chromen-2-yl]methyl 4-methylbenzenesulfonate

Product 1

HCID 44468650N-Ethyl-N-{[7-(methylsulfonyl)-3,4-dihydro-2H-chromen-2-YL]methyl}ethanamine

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation according to Example 25: [7-(methylsulfonyl)-3,4-dihydro-2H-chromen-2-yl]methyl 4-methylbenzenesulfonate (0.020 g, 0.0504 mmol), N-ethylethanamine (0.5 ml), ACN (3 ml). MS m/z (rel. intensity, 70 eV) 297 (M+, 1), 131 (4), 87 (6), 86 (bp), 58 (5), 56 (3).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-936a00956bdb4966bb3eaab137fd90b2
Source dataset
uspto-grants-2013_09
Patent number
US08524766B2

Reaction notes

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