反应详情

温度

55 °C

1.8 g of 1-(4-fluorophenyl)-2-(2-propenyloxy)ethanone obtained in Step 2, 1.21 g of potassium cyanide and 4.69 g of ammonium carbonate are heated to 55° C. for 2 hours in 50 mL of a 50/50 ethanol/water mixture. While heating the mixture at 55° C. 4.69 g of ammonium carbonate is added 3 times after 1 hour, 4 and 15 hours respectively. The reaction mixture is then diluted with water and extracted with ethyl acetate. The organic solution is dried over sodium sulfate and evaporated to provide the desired product.

1. custom4 and 15 hours
2. extractionextracted with ethyl acetate
3. dry with materialThe organic solution is dried over sodium sulfate
4. customevaporated