Water → 2-Hydroxy-3'-(trifluoromethyl)acetophenone

HRID 389890Notes

Reaction equation

HRID 389890 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([F:14])([F:13])[F:12])[CH:6]=1)=[O:4].[OH2:15]>C(#N)C>[F:12][C:11]([F:14])([F:13])[C:7]1[CH:6]=[C:5]([C:3](=[O:4])[CH2:2][OH:15])[CH:10]=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 962WaterHCID 27783862-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one

Product 1

HCID 167269582-Hydroxy-3'-(trifluoromethyl)acetophenone

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone (1 g) in acetonitrile (2.5 mL) and water (10 mL) is treated under microwave irradiation (125° C., 50 min). The same experiment is repeated five times. All the vials are collected, extracted with DCM, dried over magnesium sulfate and concentrated under vacuum to give the desired compound.

Workup

  1. customAll the vials are collected
  2. extractionextracted with DCM
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-ba55c46c5d4f44f2a5e9f3d295235304
Source dataset
uspto-grants-2013_02
Patent number
US08383608B2

Reaction notes

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