HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-Hydroxy-3'-(trifluoromethyl)acetophenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one | HCID 2778386 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-Hydroxy-3'-(trifluoromethyl)acetophenone | HCID 16726958 | — |
Reaction Steps
A solution of 2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone (1 g) in acetonitrile (2.5 mL) and water (10 mL) is treated under microwave irradiation (125° C., 50 min). The same experiment is repeated five times. All the vials are collected, extracted with DCM, dried over magnesium sulfate and concentrated under vacuum to give the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383608B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-ba55c46c5d4f44f2a5e9f3d295235304 |
| Source note | uspto-grants-2013_02 |