HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methylacetophenone → 2-Bromo-1-(3-methylphenyl)ethan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methylacetophenone | HCID 11455 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2-Bromo-1-(3-methylphenyl)ethan-1-one | HCID 10036129 | — |
Reaction Steps
To a solution of 1-(3-methylphenyl)ethanone (2 g) in ethyl ether (20 mL) is added bromine (726 μL) at 0° C. The mixture is treated with an aqueous solution of sodium bicarbonate, extracted with ethyl ether, dried over magnesium sulfate, concentrated and purified on silica gel (ethyl acetate/cyclohexane 0/100) to give the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383608B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-6dd5181a9b7a47fb8fad3019836c489d |
| Source note | uspto-grants-2013_02 |