3-Chloropropionyl chloride → 1-(4-(4-t-Butylphenyl)piperazin-1-yl)-3-chloropropan-1-one

HRID 390008Notes

Reaction equation

HRID 390008 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[Cl:17][CH2:18][CH2:19][C:20](Cl)=[O:21]>>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([N:11]2[CH2:16][CH2:15][N:14]([C:20](=[O:21])[CH2:19][CH2:18][Cl:17])[CH2:13][CH2:12]2)=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 693643-Chloropropionyl chlorideHCID 7817221-(4-tert-Butylphenyl)piperazine

Product 1

HCID 679970371-(4-(4-t-Butylphenyl)piperazin-1-yl)-3-chloropropan-1-one

Procedure

A target compound (1.59 g, 5.148 mmol, 76.4%) was yielded as liquid in the same manner as Reference Example 13 by reacting 1-(4-t-butylphenyl)piperazine (1.47 g, 6.732 mmol) with 3-chloropropionyl chloride (647.5 mg, 6.732 mmol) and purifying by separation through column chromatography (EtOAc:hexane:CH2Cl2, 1:1:5).

Workup

  1. custompurifying by separation through column chromatography (EtOAc:hexane:CH2Cl2, 1:1:5)

Sources & evidence

ORD record
ord-ff0f3269925f450fb85a48ca3b14a9c9
Source dataset
uspto-grants-2013_02
Patent number
US08383631B2

Reaction notes

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