HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloropropionyl chloride → 1-(4-(4-t-Butylphenyl)piperazin-1-yl)-3-chloropropan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloropropionyl chloride | HCID 69364 | — |
| Reactant | 1-(4-tert-Butylphenyl)piperazine | HCID 781722 | — |
| Product | 1-(4-(4-t-Butylphenyl)piperazin-1-yl)-3-chloropropan-1-one | HCID 67997037 | — |
Reaction Steps
A target compound (1.59 g, 5.148 mmol, 76.4%) was yielded as liquid in the same manner as Reference Example 13 by reacting 1-(4-t-butylphenyl)piperazine (1.47 g, 6.732 mmol) with 3-chloropropionyl chloride (647.5 mg, 6.732 mmol) and purifying by separation through column chromatography (EtOAc:hexane:CH2Cl2, 1:1:5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383631B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-ff0f3269925f450fb85a48ca3b14a9c9 |
| Source note | uspto-grants-2013_02 |