Potassium Carbonate → 3-amino-1-{(4-phenylpiperazin-1-yl)propanoyl}-6-N-{(furan-2-yl)methyl}-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-7-one

HRID 390026Notes

Reaction equation

HRID 390026 reaction equation
[NH2:1][C:2]1[C:10]2[CH2:9][CH2:8][N:7]([CH2:11][C:12]3[O:13][CH:14]=[CH:15][CH:16]=3)[C:6](=[O:17])[C:5]=2[NH:4][N:3]=1.[C:18](=[O:21])([O-])[O-].[K+].[K+].ClC[CH2:26][C:27]([N:29]1[CH2:34][CH2:33][N:32]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[CH2:31][CH2:30]1)=O>>[NH2:1][C:2]1[C:10]2[CH2:9][CH2:8][N:7]([CH2:11][C:12]3[O:13][CH:14]=[CH:15][CH:16]=3)[C:6](=[O:17])[C:5]=2[N:4]([C:18](=[O:21])[CH2:26][CH2:27][N:29]2[CH2:34][CH2:33][N:32]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)[CH2:31][CH2:30]2)[N:3]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 2467973-Chloro-1-(4-phenylpiperazin-1-yl)propan-1-oneHCID 679969813-amino-6-N-((furan-2-yl)methyl)-5,6-dihydro-1H-pyrazolo[3,4-c]pyridin-7(4H)-one

Product 1

HCID 679973163-amino-1-{(4-phenylpiperazin-1-yl)propanoyl}-6-N-{(furan-2-yl)methyl}-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-7-one

Procedure

A target compound (192.8 mg, 0.429 mmol, 96.2%) was yielded as solid in the same manner as Example 1 by reacting 3-amino-6-N-((furan-2-yl)methyl)-5,6-dihydro-1H-pyrazolo[3,4-c]pyridin-7(4H)-one (104 mg, 0.447 mmol) with potassium carbonate (92.6 mg, 0.670 mmol) and 3-chloro-1-(4-phenylpiperazin-1-yl)propan-1-one (124.1 mg, 0.491 mmol).

Sources & evidence

ORD record
ord-d98d156e730b46dbac6e22117584a33b
Source dataset
uspto-grants-2013_02
Patent number
US08383631B2

Reaction notes

Loading…