反应详情

A round bottom flask was charged with ethyl 4-methyl-2-(methylthio)-6-oxo-1,4,5,6-tetrahydro-5-pyrimidinecarboxylate (11.2 g, 48.7 mmol), N-bromo succinimide (8.67 g, 48.7 mmol), benzoyl peroxide (0.65 g, 2.7 mmol), potassium carbonate (67 g, 487 mmol) and carbon tetrachloride (700 mL). The reaction was heated to reflux for 45 min and cooled to room temperature. The reaction was quenched with to water (500 mL) and washed with methylene chloride. Aqueous phase was acidified by dropwise addition of conc. HCl and extracted with methylene chloride. The extract was dried over MgSO4, filtered, and evaporated under vacuum to afford the product (8.2 g, 78% yield).

1. temperatureThe reaction was heated
2. temperatureto reflux for 45 min
3. customThe reaction was quenched with to water (500 mL)
4. washwashed with methylene chloride
5. additionAqueous phase was acidified by dropwise addition of conc. HCl
6. extractionextracted with methylene chloride
7. dry with materialThe extract was dried over MgSO4
8. filtrationfiltered
9. customevaporated under vacuum