反应详情

A round bottom flask was charged with ethyl 4-methyl-2-(methylthio)-6-oxo-1,6-dihydro-5-pyrimidinecarboxylate (6 g) and phosphorus oxychloride (30 mL) and heated to reflux for 3 h. The phosphorus oxychloride was removed under vacuum. The residue was chromatographed (silica gel, eluting with methylene chloride) to afford the product (5.73 g, 87% yield).

1. temperatureheated
2. temperatureto reflux for 3 h
3. customThe phosphorus oxychloride was removed under vacuum
4. customThe residue was chromatographed
5. wash(silica gel, eluting with methylene chloride)