HCID 58296315, compound → HCID 58296338, compound

HRID 390042Notes

Reaction equation

HRID 390042 reaction equation
CN(C)/[CH:3]=[CH:4]/[C:5]1[N:10]=[C:9]([S:11][CH3:12])[N:8]=[C:7]2[N:13]([C:18]3[CH:23]=[CH:22][C:21]([S:24][CH3:25])=[CH:20][CH:19]=3)C=[N:15][C:16](=[O:17])[C:6]=12>C(O)(=O)C>[CH3:12][S:11][C:9]1[N:8]=[C:7]([NH:13][C:18]2[CH:19]=[CH:20][C:21]([S:24][CH3:25])=[CH:22][CH:23]=2)[C:6]2[C:16](=[O:17])[NH:15][CH:3]=[CH:4][C:5]=2[N:10]=1

Participants

3

Reactant 1

HCID 58296315HCID 58296315, compound

Product 1

HCID 58296338HCID 58296338, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A round bottom flask was charged with 5-[(E)-2-(dimethylamino)ethenyl]-7-(methylthio)-1-[4-(methylthio)phenyl]pyrimido[4,5-d]pyrimidin-4(1H)-one (0.43 g, 1.30 mmol) and acetic acid (50 mL). The reaction was stirred at reflux for 18 h and acetic acid was removed under vacuum. Methylene chloride (20 mL) was added to the residue and the product was collected by filtration (0.27 g, 75% yield).

Workup

  1. temperatureat reflux for 18 h
  2. customacetic acid was removed under vacuum
  3. additionMethylene chloride (20 mL) was added to the residue
  4. filtrationthe product was collected by filtration (0.27 g, 75% yield)

Sources & evidence

ORD record
ord-3422e7cbf2b14016bec43f031fec2e3e
Source dataset
uspto-grants-2013_02
Patent number
US08383635B2

Reaction notes

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