Trifluoroacetic acid → HCID 44818188, compound

HRID 390055Notes

Reaction equation

HRID 390055 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]1[C:10]2[C:20](=[O:21])[NH:19][CH:18]=[CH:17][C:11]=2[N:12]=[C:13](SC)[N:14]=1.C1C=C(Cl)C=C(C(OO)=O)C=1.[NH2:33][CH2:34][CH2:35][CH2:36][NH:37]C(=O)OC(C)(C)C.C(O)(C(F)(F)F)=O>>[NH2:33][CH2:34][CH2:35][CH2:36][NH:37][C:13]1[N:14]=[C:9]([NH:8][C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[CH3:1])[C:10]2[C:20](=[O:21])[NH:19][CH:18]=[CH:17][C:11]=2[N:12]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 58296339HCID 58296339, compoundHCID 86654203HCID 86654203, compound

Product 1

HCID 44818188HCID 44818188, compound

Procedure

The compound was prepared from 4-[(2-methylphenyl)amino]-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one following a procedure (mCPBA/1,1-dimethylethyl (3-aminopropyl)carbamate and TFA) similar to that described for Example 1 (Scheme 2).

Sources & evidence

ORD record
ord-4059ec80b0df4a9f89dd5156db8c4aaa
Source dataset
uspto-grants-2013_02
Patent number
US08383635B2

Reaction notes

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