Trifluoroacetic acid → HCID 44818189, compound

HRID 390057Notes

Reaction equation

HRID 390057 reaction equation
[O:1]=[S:2]1(=[O:25])[CH2:6][C:5]2[CH:7]=[CH:8][C:9]([NH:11][C:12]3[C:13]4[C:23](=[O:24])[NH:22][CH:21]=[CH:20][C:14]=4[N:15]=[C:16](SC)[N:17]=3)=[CH:10][C:4]=2[CH2:3]1.C1C=C(Cl)C=C(C(OO)=O)C=1.[NH2:37][CH2:38][CH2:39][CH2:40][NH:41]C(=O)OC(C)(C)C.C(O)(C(F)(F)F)=O>>[NH2:37][CH2:38][CH2:39][CH2:40][NH:41][C:16]1[N:17]=[C:12]([NH:11][C:9]2[CH:8]=[CH:7][C:5]3[CH2:6][S:2](=[O:1])(=[O:25])[CH2:3][C:4]=3[CH:10]=2)[C:13]2[C:23](=[O:24])[NH:22][CH:21]=[CH:20][C:14]=2[N:15]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 58296319HCID 58296319, compoundHCID 86654203HCID 86654203, compound

Product 1

HCID 44818189HCID 44818189, compound

Procedure

The compound was prepared from 4-[(2,2-dioxido-1,3-dihydro-2-benzothien-5-yl)amino]-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one using mCPBA/1,1-dimethylethyl (3-aminopropyl)carbamate and TFA sequences similar to that described for Example 1 (Scheme 2).

Sources & evidence

ORD record
ord-2872adac216549c5aed894c1a4368eb1
Source dataset
uspto-grants-2013_02
Patent number
US08383635B2

Reaction notes

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