Trifluoroacetic acid → HCID 44818365, compound

HRID 390060Notes

Reaction equation

HRID 390060 reaction equation
CS[C:3]1[N:4]=[C:5]([NH:14][C:15]2[CH:16]=[C:17]([NH:21][C:22]([N:24]3[CH2:28][CH2:27][CH2:26][CH2:25]3)=[O:23])[CH:18]=[CH:19][CH:20]=2)[C:6]2[C:12](=[O:13])[NH:11][CH:10]=[CH:9][C:7]=2[N:8]=1.C1C=C(Cl)C=C(C(OO)=O)C=1.[NH2:40][CH2:41][CH2:42][CH2:43][NH:44][C:45](=O)OC(C)(C)C.C(O)(C(F)(F)F)=O>>[O:13]=[C:12]1[C:6]2[C:5]([NH:14][C:15]3[CH:16]=[C:17]([NH:21][C:22]([N:24]4[CH2:28][CH2:27][CH2:26][CH2:25]4)=[O:23])[CH:18]=[CH:19][CH:20]=3)=[N:4][C:3]([NH:40][C@@H:41]3[CH2:42][CH2:43][NH:44][CH2:45]3)=[N:8][C:7]=2[CH:9]=[CH:10][NH:11]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 58296333HCID 58296333, compoundHCID 86654203HCID 86654203, compound

Product 1

HCID 44818365HCID 44818365, compound

Procedure

The compound was prepared from N-(3-{[2-(methylthio)-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-4-yl]amino}phenyl)-1-pyrrolidinecarboxamide using m-CPBA/1,1-dimethylethyl (3-aminopropyl)carbamate and TFA sequences similar to that described for Example 1 (Scheme 2).

Sources & evidence

ORD record
ord-8498fbd6fbe94ca3820c34ad49be7fd2
Source dataset
uspto-grants-2013_02
Patent number
US08383635B2

Reaction notes

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