反应详情

4-[(3-methylphenyl)amino]-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one (500 mg, 1.676 mmol) was dissolved into N,N-Dimethylformamide (DMF) (8 mL) and NBS (298 mg, 1.676 mmol) was added. The reaction mixture was stirred at rt for 2 h. It was quenched with water (12 mL) and EtOAc (5 mL) was added. The mixture was filtered to collect the precipitate, which was further dried under high vacuum to give 470 mg of crude product (83% pure based on LC-MS).

1. additionwas added
2. customIt was quenched with water (12 mL) and EtOAc (5 mL)
3. additionwas added
4. filtrationThe mixture was filtered
5. customto collect the precipitate, which
6. customwas further dried under high vacuum