Trifluoroacetic acid → HCID 44623930, compound

HRID 390066Notes

Reaction equation

HRID 390066 reaction equation
[CH3:1][N:2]([CH2:10][C:11]([NH:13][CH2:14][CH2:15][CH2:16][NH:17][C:18]1[N:19]=[C:20]([NH:29][C:30]2[CH:35]=[CH:34][CH:33]=[C:32]([CH3:36])[CH:31]=2)[C:21]2[C:27](=[O:28])[NH:26][CH:25]=[CH:24][C:22]=2[N:23]=1)=[O:12])C(=O)OC(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[CH3:1][NH:2][CH2:10][C:11]([NH:13][CH2:14][CH2:15][CH2:16][NH:17][C:18]1[N:19]=[C:20]([NH:29][C:30]2[CH:35]=[CH:34][CH:33]=[C:32]([CH3:36])[CH:31]=2)[C:21]2[C:27](=[O:28])[NH:26][CH:25]=[CH:24][C:22]=2[N:23]=1)=[O:12]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58296303HCID 58296303, compound

Product 1

HCID 44623930HCID 44623930, compoundYield 124.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1,1-dimethylethyl methyl(2-{[3-({4[(3-methylphenyl)amino]-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl}amino)propyl]amino}-2-oxoethyl)carbamate (30 mg, 0.061 mmol) in Dichloromethane (DCM) (1 mL) was added TFA (0.5 mL, 6.49 mmol), and the reaction mixture was stirred for 1.5 h. It was concentrated and the residue was further dried under high vacuum to give 30 mg of pure product.

Workup

  1. concentrationIt was concentrated
  2. customthe residue was further dried under high vacuum

Sources & evidence

ORD record
ord-e77687199dfc45e1a4e6df00f1b8f7a0
Source dataset
uspto-grants-2013_02
Patent number
US08383635B2

Reaction notes

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