反应详情

Preparation according to Preparation 21 using [(2S)-7-bromo-5-fluoro-2,3-dihydro-1,4-benzodioxin-2-yl]methanol (2.35 g, 8.9 mmol), sodium methanesulfinate (85%) (1.29 g, 107 mmol), CuI (0.34 g, 1.8 mmol), L-proline (0.41 g, 3.6 mmol) and NaOH (0.071 g, 1.8 mmol) in DMSO (6 ml). Yield 0.98 g. MS m/z (rel. intensity, 70 eV) 262 (M+, bp), 231 (35), 183 (22), 152 (23), 57 (30).

1. customPreparation