反应详情

温度

150 °C

A mixture of 2,6-dichloro-4-iodopyridine (5 g, 18.3 mmol) and cyclohexylamine (18.1 g, 183 mmol) was heated in a Biotage Initiator microwave at 150° C. for 30 min. Ethyl acetate (150 mL) was added and the mixture washed with water (100 mL) and brine (50 mL). The organics were concentrated and the residual oil purified by flash chromatography on silica gel eluting with 10% ethyl acetate in hexanes to provide the title compound. Yield: 4.7 g (76%). MS (DCI/NH3) m/z 337 (M+H)+.

1. washthe mixture washed with water (100 mL) and brine (50 mL)
2. concentrationThe organics were concentrated
3. customthe residual oil purified by flash chromatography on silica gel eluting with 10% ethyl acetate in hexanes