反应详情

温度

65 °C

A mixture of 2-chloro-6-fluorophenol (25 g, 170 mmol), acetone (200 ml), K2CO3 (47.08 g, 340 mmol) and bensylbromide (22.31 ml, 187 mmol) was heated at 65° C. for 16 h. The solution was filtered and evaporated. Water (100 ml) was added, and the solution was extracted with EtOAc. The combined organic phases were dried (Na2SO4) and evaporated to dryness to give the title compound (32.3 g). MS m/z (rel. intensity, 70 eV) 236 (M+, 2), 117 (4), 92 (8), 91 (bp), 65 (13).

1. filtrationThe solution was filtered
2. customevaporated
3. additionWater (100 ml) was added
4. extractionthe solution was extracted with EtOAc
5. dry with materialThe combined organic phases were dried (Na2SO4)
6. customevaporated to dryness