Ammonia → HCID 58295791, compound

HRID 390152Notes

Reaction equation

HRID 390152 reaction equation
[NH3:1].[F:2][C:3]1[CH:30]=[C:29]2[C:6]([CH:7]([CH2:31][C:32](O)=[O:33])[CH2:8][C:9]32[CH2:14][CH2:13][N:12]([C:15](=[O:28])/[CH:16]=[CH:17]/[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[C:24]([F:27])([F:26])[F:25])[CH2:11][CH2:10]3)=[CH:5][CH:4]=1>O1CCOCC1>[F:2][C:3]1[CH:30]=[C:29]2[C:6]([CH:7]([CH2:31][C:32]([NH2:1])=[O:33])[CH2:8][C:9]32[CH2:10][CH2:11][N:12]([C:15](=[O:28])/[CH:16]=[CH:17]/[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[C:24]([F:26])([F:25])[F:27])[CH2:13][CH2:14]3)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 58295703HCID 58295703, compound

Product 1

HCID 58295791HCID 58295791, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The title compound was prepared following a procedure analogous to that described in Example 7 using 0.5 M NH3 in dioxane and (±)-(E)-2-(6-fluoro-1′-(3-(2-(trifluoromethyl)phenyl)acryloyl)-2,3-dihydrospiro[indene-1,4′-piperidine]-3-yl)acetic acid. LC-MS Method 1 tR=1.67, min, m/z=461.

Sources & evidence

ORD record
ord-b62efa0a040a497186686003e86c701d
Source dataset
uspto-grants-2013_02
Patent number
US08383629B2

Reaction notes

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