Potassium Hydroxide → [(2S)-8-Fluoro-2,3-dihydro-1,4-benzodioxin-2-YL]methanol

HRID 39018Notes

Reaction equation

HRID 39018 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH2:9][CH:10]2[CH2:12][O:11]2)[C:3]=1[OH:13].[OH-].[K+]>O1CCOCC1>[F:1][C:2]1[C:3]2[O:13][C@@H:10]([CH2:12][OH:11])[CH2:9][O:8][C:4]=2[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 86652950HCID 86652950, compound

Product 1

HCID 54461939[(2S)-8-Fluoro-2,3-dihydro-1,4-benzodioxin-2-YL]methanol

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Preparation according to Preparation 20 using 2-fluoro-6-(oxiran-2-ylmethoxy)phenol (3.9 g, 21.2 mmol), dioxane (20 ml) and KOH (10%, 10 ml). The mixture stirred at RT for 1.5 h. Yield 3.8 g. MS m/z (rel. intensity, 70 eV) 338 (50), 166 (bp), 165 (42), 139 (24), 91 (51).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-6c5afa6cfb53451ba6c1042974bb7319
Source dataset
uspto-grants-2013_09
Patent number
US08524766B2

Reaction notes

Loading…