HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → [(2S)-8-Fluoro-2,3-dihydro-1,4-benzodioxin-2-YL]methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | HCID 86652950 | HCID 86652950 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | [(2S)-8-Fluoro-2,3-dihydro-1,4-benzodioxin-2-YL]methanol | HCID 54461939 | — |
Reaction Steps
Preparation according to Preparation 20 using 2-fluoro-6-(oxiran-2-ylmethoxy)phenol (3.9 g, 21.2 mmol), dioxane (20 ml) and KOH (10%, 10 ml). The mixture stirred at RT for 1.5 h. Yield 3.8 g. MS m/z (rel. intensity, 70 eV) 338 (50), 166 (bp), 165 (42), 139 (24), 91 (51).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524766B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-6c5afa6cfb53451ba6c1042974bb7319 |
| Source note | uspto-grants-2013_09 |