2-Methylspiro[isoindoline-3,4'-piperidine]-1-one → 2-Methyl-1'-(3-(2-(trifluoromethyl)phenyl)propanoyl)spiro[isoindoline-1,4'-piperidin]-3-one
Reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][C:11]([OH:13])=O.[CH3:16][N:17]1[C:25]2([CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:18]1=[O:31]>>[CH3:16][N:17]1[C:25]2([CH2:30][CH2:29][N:28]([C:11](=[O:13])[CH2:10][CH2:9][C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=3[C:2]([F:1])([F:15])[F:14])[CH2:27][CH2:26]2)[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:18]1=[O:31]Participants
3
Procedure
The title compound was prepared following a procedure analogous to that described in Example 1 using 3-(2-(trifluoromethyl)phenyl)propanoic acid and 2-methylspiro[isoindoline-1,4′-piperidin]-3-one. LC-MS Method 1 tR=1.65, min, m/z=417, 415.
Sources & evidence
- ORD record
- ord-65e20ce5741449bfa5870697c8e63531
- Source dataset
- uspto-grants-2013_02
- Patent number
- US08383629B2
Reaction notes
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